Little evidence from trials exists to evaluate the effect of vitamin D supplementation during pregnancy on maternal, perinatal or infant health outcomes. No effect on preterm delivery (<37 weeks) was evident (2 trials, RR=0.77 ). Pooled analysis of trials using fixed effects models suggested protective effects of supplementation on low birthweight (3 trials, Risk ratio (RR)=0.40 ) and non-significant but suggestive effects of daily supplementation on small-for-gestational age (SGA) (2 trials, RR=0.67. All had small sample size and dosage amount, duration, and frequency varied as did the ability to correct deficiency. We identified 5 randomized trials with outcomes of relevance to our review. Meta-analysis was used to pool effect estimates.
Data from trials and observational studies isolating the effect of vitamin D supplementation and intake were extracted and study quality was evaluated.
There has been considerable recent interest in the role of vitamin D on outcomes related to pregnancy and young child health but few efforts have been made to systematically consolidate this evidence to inform the research and policy agenda for low income countries.Ī systematic review was undertaken to identify intervention and observational studies of vitamin D supplementation, intake, or status (25-hydroxy-vitamin D) during pregnancy on perinatal and infant health outcomes. Vitamin D has well-defined classical functions related to calcium metabolism and bone health but also has non-classical effects that may influence other aspects of health. Prospective observational studies of the relationship between maternal blood levels of 25(OH)D during pregnancy and pre-eclampsia Prospective observational studies of the relationship between maternal blood levels of 25(OH)D during pregnancy and measures of fetal growth, birth weight, and preterm birth Evaluation of the quality of evidence of individual observational studies for potential inclusion in the meta-analysis Evaluation of the quality of eligible trials for potential inclusion in the meta-analysis Observational studies of vitamin D intake and pre-eclampsia risk Observational studies of vitamin D intake and mean gestational age at deliveryįigure S7. Supplementation and preterm and mean gestational age at delivery, disaggregated by dosing approachįigure S6. Trials of vitamin D supplementation and mean weight gain during the 3 rd trimesterįigure S5. Trials of vitamin D supplementation and mean crown-heel length (in cm.)įigure S4. Trials of vitamin D supplementation and SGA and low birthweight, disaggregated by dosing approachįigure S3. Trials and observational studies of vitamin D supplementation or intake and mean birthweight (in grams)įigure S2.
0 kommentar(er)
